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Amoxicillin and Clavulanic Acid

Selected References:

  • Benyamini L, Merlob et al. 2005. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit27:499-502.
  • Berkovitch M, et al. 2004 First-trimester exposure to amoxicillin/clavulanic acid: a prospective controlled study. Br J Clin Pharmacol; 58:298-302.
  • Campbell AC, et al. 1991 The excretion of amoxicillin in breastmilk and its effect on the suckling infant. Br J Clin Pharmacol; 31:230p.
  • Czeizel AE, et al. 2001.Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study. Eur J Obstet Gynecol Reprod Biol97:188-92.
  • Daniel S, et.al, 2019. The safety of amoxicillin and clavulanic acid use in the rist trimester of pregnancy. Br J Clin Pharmacol; 85:2856-63.
  • Grantham J, et al. 2002. Association between co-amoxiclav used antenatally with necrotising enterocolitis in the neonate. Am J Obstet Gynecol187:S90.
  • Jepsen P, et al. 2003. A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark. Br J Clin Pharmacol55:216-221.
  • Kafetzis D, et al. 1981. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand 70:285-8.
  • Kenyon SL, et al. 2001. ORACLE Collaborative Group. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet 357:979-88.
  • Kenyon SL, et al. 2001. ORACLE Collaborative Group. Broad-spectrum antibiotics for spontaneous preterm labour: the ORACLE II randomised trial. ORACLE Collaborative Group. Lancet357:989-94.
  • Kenyon S, et al. 2002. ORACLE–antibiotics for preterm prelabour rupture of the membranes: short-term and long-term outcomes. Acta Paediatr Suppl 437:12-15.
  • Kenyon S, et al. 2008. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372(9646):1319-27.
  • Kenyon S, et al. 2013. Preterm Labour, Antibiotics and Cerebral Palsy. Scientific Impact Paper No.33, Royal College of Obstetrics and Gynaecologists.
  • Lin KJ, et al. 2012. Maternal exposure to amoxicillin and the risk of oral clefts. Epidemiology 23(5):699-705.
  • Marlow N, et al. 2017. The ORACLE Children Study: educational outcomes at 11 years of age following antenatal prescription of erythromycin or co-amoxiclav. Arch Dis Child Fetal Neonatal Ed 102(2): F131-F135.
  • Meeraus WH, et al. 2015. Association between antibiotic prescribing in pregnancy and cerebral palsy or epilepsy in children born at term: A cohort study using the health improvement network.PLoS ONE 10(3):e0122034.
  • Mercer BM, et al. 1997. Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. JAMA 278:989-995.
  • Merkel TA, et al. 2014. Predicting disease severity of necrotizing enterocolitis: how to identify infants for future novel therapies. J Clin Neonatol. 3(1):1-9.
  • Padberg, S. 2015. Anti-infective Agents. In C Schaefer, P Peters, R Miller (Eds.), Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. Pg 116. London: Elsevier.
  • Puho EH, et al. 2007. Drug treatment during pregnancy and isolated orofacial clefts in Hungary. Cleft Palate Craniofac J44:194-202.

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