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Fluphenazine (Prolixin®, Permitil®)

Selected References:

  • Aleem M, Choudhari J, Padwal V, Balasinor N, Parte P, Gill-Sharma MK: Hyperprolactinemia affects spermiogenesis in adult male rats. Journal of Endocrinological Investigation 2005; 28(1):39-48.
  • Auerbach JG, et al. 1992. Maternal psychotropic medication and neonatal behavior. Neurotoxicol Teratol 14(6):399-406.
  • Cleary MF. 1977. Fluphenazine decanoate during pregnancy. Am J Psychiat 134:815-6.
  • Einarson A, Boskovic R. 2009. Use and safety of antipsychotic drugs during pregnancy. J Psychiatr Pract. 15(3):183-92.
  • 2011. Drug Safety Communication: Antipsychotic drug labels updated on use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns (issued 2/2011). https://www.fda.gov/Drugs/DrugSafety/ucm243903.htm
  • (2018, October 31). Retrieved from https://toxnet.nlm.nih.gov/cgi-bin/sis/search2
  • Gill-Sharma MK, Aleem M, Sethi G, Choudhary J, Padwal V, D’Souza S, Balasinor N, Parte P, Juneja HS: Antifertility effects of fluphenazine in adult male rats. Journal of Endocrinological Investigation 2003; 26(4):316-26.
  • Gomez EA: Hypersexuality in men receiving fluphenazine decanoate (letter). Am J Psychiatry 138:1263, 1981.
  • Kopf GS, Vacquier VD: Characterization of a calmodulin-stimulated adenylate cyclase from abalone spermatozoa. J Biol Chem 259:7590-6, 1984.Holt RI, Peveler RC. 2011. Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management. Clin Endocrinol (Oxf). 74(2):141-7.
  • Maguire GA. 2002. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 63(suppl 4):56-62.
  • Mogwitz S, et al. 2018. Update on the Pharmacological Treatment of Tics with Dopamine-Modulating Agents. ACS Chem Neurosci. 9(4):651-672.
  • Nath SP, et al. 1996. Severe rhinorrhea and respiratory distress in a neonate exposed to fluphenazine hydrochloride prenatally. Ann Pharmacotherapy 30:35-7.
  • Serres C, Kahn ML: Motility induction in hamster spermatozoa from caput epididymis: effect of forward motility protein (FMP) and calmodulin inhibitor. Reprod Nutr Dev 24:81-94, 1984.
  • Siragusa S, et al. 2022. Fluphenazine. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;. https://www.ncbi.nlm.nih.gov/books/NBK459194/.

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